English epidemiologist David Barker and his associates at the University of Southampton discovered much of what is known about the lifelong impact of early growth and development. Their pioneering work has ushered in a new field of medicine and a whole new way of promoting health and preventing disease.
"Fetal programming" is the phrase often used to describe permanent changes resulting from the prenatal environment.21
Before and/or during pregnancy...
When a mother lacks: | …Then her baby is more likely to develop: |
---|---|
Folic acid | Spina bifida,22 preterm birth23 |
Iodine | Brain damage,24 hypothyroidism25 |
Vitamin D | Osteoporosis26 |
Vitamin E | Asthma27 |
During pregnancy...
When a mother: | …Then her baby is more likely to develop: |
---|---|
Experiences excess stress and anxiety | Attention Deficit Hyperactivity Disorder (ADHD) and anxiety28 |
Smokes cigarettes | ADHD,29 conduct disorder,30 obesity,31 diabetes,32 heart disease,33 preterm birth,34 stillbirth,35 SIDS*36 |
Drinks alcohol | Fetal Alcohol Syndrome,37 alcohol abuse,38 conduct disorder,39 ADHD,40 preterm birth41 |
*Sudden Infant Death Syndrome
It is important to keep in mind that, although these prenatal factors increase the risk of certain complications, they in no way guarantee that any complication will occur.
Anyone who experienced a less-than-ideal pregnancy should not panic or lose hope. Even if a problem develops, most are treatable and many have other risk factors that can be modified to minimize risk. The good news is that new ways to minimize long-term consequences have already been discovered.42
Nevertheless, given the many associations between prenatal events and lifelong health that have been reported worldwide, it is imperative to do all we can to improve women's health and nutrition starting long before pregnancy and during pregnancy and breastfeeding.
When Health Begins brochure/poster, Page 3 Back to Top
Bibliography
Bergen HT. 2006. Exposure to Smoke During Development: Fetal Programming of Adult Disease. Tobacco Induced Diseases. Vol. 3, No. 2:5-16.
Search EHD
Ong KK, Dunger DB. 2002. Perinatal growth failure: the road to obesity, insulin resistance and cardiovascular disease in adults. Best Pract Res Clin Endocrinol Metab. 16:191-207.
Search EHD Ref. / Abstract Full Text
Barker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ. 1989. Weight in infancy and death from ischaemic heart disease. Lancet. 2:577-580.
Search EHD Ref. / Abstract
Montgomery SM, Ekbom A. 2002. Smoking during pregnancy and diabetes mellitus in a British longitudinal birth cohort. BMJ. 324:26-27.
Search EHD Ref. / Abstract Full Text
von Kries R, Toschke AM, Koletzko B, Slikker W, Jr. 2002. Maternal smoking during pregnancy and childhood obesity. Am J Epidemiol. 156:954-961.
Search EHD Ref. / Abstract Full Text
Dubois L, Girard M. 2006. Early determinants of overweight at 4.5 years in a population-based longitudinal study. Int J Obes (Lond). 30:610-617.
Search EHD Ref. / Abstract Full Text
Power C, Jefferis BJ. 2002. Fetal environment and subsequent obesity: a study of maternal smoking. Int J Epidemiol. 31:413-419.
Search EHD Ref. / Abstract Full Text
Adams AK, Harvey HE, Prince RJ. 2005. Association of maternal smoking with overweight at age 3 y in American Indian children. Am J Clin Nutr. 82:393-398.
Search EHD Ref. / Abstract Full Text
Barker DJ. 1999. Early growth and cardiovascular disease. Arch Dis Child. Apr;80(4):305-7.
Search EHD Ref. / Abstract Full Text
Eriksson JG, Yliharsila H, Forsen T, Osmond C, Barker DJ. 2004. Exercise protects against glucose intolerance in individuals with a small body size at birth. Prev Med. Jul;39(1):164-7.
Search EHD Ref. / Abstract Full Text
Griesler PC, Kandel DB. 1998. The impact of maternal drinking during and after pregnancy on the drinking of adolescent offspring. J Stud Alcohol. 1998 May;59(3):292-304.
Search EHD Ref. / Abstract
Goldschmidt L, Richardson GA, Stoffer DS, Geva D, Day NL. 1996. Prenatal alcohol exposure and academic achievement at age six: a nonlinear fit. Alcohol Clin Exp Res. Jun;20(4):763-70.
Search EHD Ref. / Abstract Full Text
Fryer SL, McGee CL, Matt GE, Riley EP, Mattson SN. 2007. Evaluation of psychopathological conditions in children with heavy prenatal alcohol exposure. Pediatrics. Mar;119(3):e733-41.
Search EHD Ref. / Abstract Full Text
Fergusson DM, Woodward LJ, Horwood LJ. 1998. Maternal smoking during pregnancy and psychiatric adjustment in late adolescence. Arch Gen Psychiatry. Aug;55(8):721-7.
Search EHD Ref. / Abstract Full Text
Wakschlag LS, Lahey BB, Loeber R, Green SM, Gordon RA, Leventhal BL. 1997. Maternal smoking during pregnancy and the risk of conduct disorder in boys. Arch Gen Psychiatry. Jul;54(7):670-6.
Search EHD Ref. / Abstract
Linnet KM, Dalsgaard S, Obel C, Wisborg K, Henriksen TB, Rodriguez A, Kotimaa A, Moilanen I, Thomsen PH, Olsen J, Jarvelin MR. 2003. Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence. Am J Psychiatry. Jun;160(6):1028-40.
Search EHD Ref. / Abstract Full Text
Cooper C, Javaid K, Westlake S, Harvey N, Dennison E. 2005. Developmental origins of osteoporotic fracture: the role of maternal vitamin D insufficiency. J Nutr. Nov;135(11):2728S-34S.
Search EHD Ref. / Abstract Full Text
Baer JS, Sampson PD, Barr HM, Connor PD, Streissguth AP. 2003. A 21-year longitudinal analysis of the effects of prenatal alcohol exposure on young adult drinking. Arch Gen Psychiatry. Apr;60(4):377-85.
Search EHD Ref. / Abstract Full Text
Litonjua AA, Rifas-Shiman SL, Ly NP, Tantisira KG, Rich-Edwards JW, Camargo CA Jr, Weiss ST, Gillman MW, Gold DR. 2006. Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age. Am J Clin Nutr. Oct;84(4):903-11.
Search EHD Ref. / Abstract Full Text
Williams JL, Abelman SM, Fassett EM, Stone CE, Petrini JR, Damus K, Mulinare J. 2006. Health care provider knowledge and practices regarding folic acid, United States, 2002-2003. Matern Child Health J. Sep;10(5 Suppl):S67-72.
Search EHD Ref. / Abstract Full Text
Brooks DR, Mucci LA, Hatch EE, Cnattingius S. 2004. Maternal smoking during pregnancy and risk of brain tumors in the offspring. A prospective study of 1.4 million Swedish births. Cancer Causes Control. Dec;15(10):997-1005.
Search EHD Ref. / Abstract Full Text
Fasting MH, Oien T, Storrø O, Nilsen TI, Johnsen R, Vik T. 2008. Maternal smoking cessation in early pregnancy and offspring weight status at four years of age. A prospective birth cohort study. Early Hum Dev. Jul 2.
Search EHD Ref. / Abstract Full Text
Spong CY. 2007. Prediction and prevention of recurrent spontaneous preterm birth. Obstet Gynecol. Aug;110(2 Pt 1):405-15.
Search EHD Ref. / Abstract Full Text
Langley K, Holmans PA, van den Bree MB, Thapar A. 2007. Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of Attention Deficit Hyperactivity Disorder and associated antisocial behaviour: investigation in a clinical sample. BMC Psychiatry. Jun 20;7:26.
Search EHD Ref. / Abstract Full Text
Salihu HM, Wilson RE. 2007. Epidemiology of prenatal smoking and perinatal outcomes. Early Hum Dev. Nov;83(11):713-20.
Search EHD Ref. / Abstract Full Text
Millichap JG. 2008. Etiologic classification of attention-deficit/hyperactivity disorder. Pediatrics. Feb;121(2):e358-65.
Search EHD Ref. / Abstract Full Text
Van den Bergh BR, Marcoen A. 2004. High antenatal maternal anxiety is related to ADHD symptoms, externalizing problems, and anxiety in 8- and 9-year-olds. Child Dev. Jul-Aug;75(4):1085-97.
Search EHD Ref. / Abstract Full Text
Chong DS, Yip PS, Karlberg J. 2004. Maternal smoking: an increasing unique risk factor for sudden infant death syndrome in Sweden. Acta Paediatr. Apr;93(4):471-8.
Search EHD Ref. / Abstract Full Text
Cnattingius S, Granath F, Petersson G, Harlow BL. 1999. The influence of gestational age and smoking habits on the risk of subsequent preterm deliveries. N Engl J Med. Sep 23;341(13):943-8.
Search EHD Ref. / Abstract Full Text
FASD: What Everyone Should Know. FASD: What Everyone Should Know. National Organization on Fetal Alcohol Syndrome Website. National Organization on Fetal Alcohol Syndrome.
Search EHD Full Text
World Health Organization. 2002. The world health report 2002 - Reducing Risks, Promoting Healthy Life. WHO Website. World Health Organization.
Search EHD Full Text
Devereux G, Turner SW, Craig LC, McNeill G, Martindale S, Harbour PJ, Helms PJ, Seaton A. 2006. Low maternal vitamin E intake during pregnancy is associated with asthma in 5-year-old children. Am J Respir Crit Care Med. Sep 1;174(5):499-507.
Search EHD Ref. / Abstract Full Text
Williams LJ, Rasmussen SA, Flores A, Kirby RS, Edmonds LD. 2005. Decline in the prevalence of spina bifida and anencephaly by race/ethnicity: 1995-2002. Pediatrics. Sep;116(3):580-6.
Search EHD Ref. / Abstract Full Text
International Diabetes Federation. 2002. Experts reach consensus on causes of Type 2 diabetes. International Diabetes Federation Website. International Diabetes Federation.
Search EHD Full Text
Braun JM, Kahn RS, Froehlich T, Auinger P, Lanphear BP. 2006. Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children. Environ Health Perspect. Dec;114(12):1904-9.
Search EHD Ref. / Abstract Full Text
Sokol RJ, Janisse JJ, Louis JM, Bailey BN, Ager J, Jacobson SW, Jacobson JL. 2007. Extreme prematurity: an alcohol-related birth effect. Alcohol Clin Exp Res. Jun;31(6):1031-7.
Search EHD Ref. / Abstract
Javaid MK, Crozier SR, Harvey NC, Gale CR, Dennison EM, Boucher BJ, Arden NK, Godfrey KM, Cooper C; Princess Anne Hospital Study Group. 2006. Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet. Jan 7;367(9504):36-43.
Search EHD Ref. / Abstract
Bukowski R, Malone FD, Porter FT, Nyberg DA, Comstock CH, Hankins GD, Eddleman K, Gross SJ, Dugoff L, Craigo SD, Timor-Tritsch IE, Carr SR, Wolfe HM, D'Alton ME. 2009. Preconceptional folate supplementation and the risk of spontaneous preterm birth: a cohort study. PLoS Med. May 5;6(5):e1000061.
Search EHD Ref. / Abstract
Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J, O'Heir CE, Mitchell ML, Hermos RJ, Waisbren SE, Faix JD, Klein RZ. 1999. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med. Aug 19;341(8):549-55.
Search EHD Ref. / Abstract
Barker DJP. 1998. Mothers, babies and health in later life, Second edition. Churchill Livingstone.
Search EHD